Keratohyalin granules are storage sites for several different proteins in addition to profilaggrin, where they are sequestered from other cellular constituents until. The term keratohyalin was introduced by Waldeyer (cited by Matoltsy and Matoltsy ) for components of cytoplasmic granules of the mammalian epidermis. ABSTRACT. Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the use of citric acid and a detergent.
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Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the graules of citric acid and a detergent. The isolated granules revealed a fine granular substructure in the electron microscope similar to that seen in situ.
Analyses of amino acids by automated column-chromatography showed that proline and cystine are present in large proportions whereas histidine is present in a small amount. Accordingly, it was concluded that keratohyalin represents a sulfur-rich amorphous precursor of the horny cell content, rather than a sulfur-poor side product of the keratinization process, or a unique histidine-rich protein as proposed by in situ histochemical and radioautographic studies.
Keratohyalin – Wikipedia
National Center for Biotechnology InformationU. Journal List J Granjles Biol v. Gedeon Matoltsy and Margit N. Author information Article notes Copyright and License information Disclaimer. Received Mar 30; Revised Jun This article is distributed under the terms of an Attribution—Noncommercial—Share Alike—No Mirror Sites license for the first six months after the publication date see http: This article has been cited by other articles in PMC.
Abstract Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the use of citric acid and a detergent. Histochemical demonstration of protein-bound sulfhydryl groups. Observations on epidermal differentiation in the fetal rat. The histochemistry of psoriasis. Ann N Y Acad Sci.
Histidine and keratohyalin granules. Ultrastructural autoradiographic studies of keratohyalin granule formation.
Sulfur-containing proteins and epidermal keratinization. Differentially localized incorporation of amino acids in relation to epidermal keratinization in the newborn rat.
Studies on localization of “histidine-rich” peptide material present in epidermis of the newborn rat. Protein synthesis related to epidermal differentiation.
Aldehyde-fuchsin-positive material of the posterior pituitary; its nature and significance. Formation of horny cells: A study of morphological and chemical properties of keratohyalin granules.
The morphology of keratohyalin granules in orthokeratotic and parakeratotic skin and oral mucosa.